Grids - 2 Columns

The "two-column grid" allows considerable flexibility and is easily workable in most page sizes. It can be subdivided into four columns and gives you a number of options for spanning 2, 3, or all 4 columns as needed.

3. Dividing the page vertically will also help keep your layout consistent. You would base this division on your leading, and it will help you figure what extra space you may have to build into your heading styles to keep your body text baselines on the vertical grid throughout.